This course introduces current topics and advances in Biochemistry and engages students in the scope and activities of the discipline. It examines the central role of water in biological systems, leading to an introduction of acid-base equilibria, the properties of biological membranes, and the bioenergetics of solutes moving across membranes. It introduces the principles of carbon bonding and electronegativity, leading to coverage of the bioorganic functional groups, whose characteristic properties and reactions combine to create the highly complex biological macromolecule classes of carbohydrates, proteins,nucleic acids, and lipids. (Format: Lecture 3 Hours, Tutorial 1.5 Hours) (Distribution: Natural Science-b) Tuesday and Thursday 10:00 to 11:20AM Crabtree M14.
This course focuses on experiential analysis and computer modeling of key concepts of the molecular basis of biology, including nucleic acid structure, synthesis, and replication through template-directed polymerizations. The course builds on these key concepts to explore gene structure, expression, and engineering, leading to the wide-ranging applications of molecular biology to biology, medicine, and diagnostics. [Note 1: This course is cross-listed as BIOL 3031 and may therefore count as 3 credits in either discipline. Note 2: This course is required for students completing a Major or Honours in Biochemistry. It is open to students from other programs on a space available basis, provided that the student has met the prerequisite requirement.] (Format: Integrated Lecture and Laboratory, 6 Hours) (Exclusion: BIOC 3021; BIOC 3531) Wednesday 12:30 to 5:20PM Barclay 201.
This course interlinks structural, mechanistic, and regulatory aspects of nucleic acid function. It explores the structures of DNA and RNA and how DNA assembles into chromosomes. It also reviews the mechanisms of DNA replication, repair, recombination, transcription, and RNA splicing. It examines the complexity and ingenuity of gene regulation in both prokaryotes and eukaryotes. (Format: Lecture 3 Hours) (Exclusion: BIOC 4911 Nucleic Acids) Monday Wednesday and Friday 9:30 to 10:20AM Avard Dixon 112.
This course examines the relations between protein structure and function at the primary, secondary, tertiary, and quaternary levels; enzyme catalysis and mechanism; isolation, purification, and characterization of proteins; the metabolism of proteins through synthesis and degradation; and recent trends in protein design. Students learn sequence comparison, motif searching, and development of visual protein structures constructed from the protein structural data bases available over the web. The course introduces mass spectroscopic analyses of the proteome and protein sequencing. (Format: Lecture 3 Hours, Laboratory 3 Hours) Tuesday and Thursday 11:30 to 12:50PM Crabtree M2.
This course covers the metabolism of major classes of lipids, their roles in signal transduction, and their interactions with proteins. (Format: Lecture 3 Hours) Tuesday and Thursday 10:00 to 11:20AM Sir James Dunn Building 106.
This is a seminar course for Honours students in Biochemistry, which critically evaluates a wide range of topics from the current literature. Students are expected to deliver seminars on topics outside their thesis areas and to present preliminary thesis results. (Format: Seminar 3 Hours) Monday Wednesday and Friday 11:30 to 12:20PM Ralph Pickard Bell Library 316.