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This course examines the roles metals play in biochemical systems, and includes an overview of bioinorganic chemistry and a discussion of metals in medicine. [Note 1: This course is cross-listed with CHEM 4351 and may therefore count as three credits in either discipline.] (Format: Lecture 3 Hours) Tuesday and Thursday 10:00 to 11:20AM Barclay 115.
This course examines the relations between protein structure and function at the primary, secondary, tertiary, and quaternary levels; enzyme catalysis and mechanism; isolation, purification, and characterization of proteins; the metabolism of proteins through synthesis and degradation; and recent trends in protein design. Students learn sequence comparison, motif searching, and development of visual protein structures constructed from the protein structural data bases available over the web. The course introduces mass spectroscopic analyses of the proteome and protein sequencing. (Format: Lecture 3 Hours, Laboratory 3 Hours) Tuesday and Thursday 11:30 to 12:50PM Barclay 115.
This course interlinks structural, mechanistic, and regulatory aspects of nucleic acid function. It explores the structures of DNA and RNA and how DNA assembles into chromosomes. It also reviews the mechanisms of DNA replication, repair, recombination, transcription, and RNA splicing. It examines the complexity and ingenuity of gene regulation in both prokaryotes and eukaryotes. (Format: Lecture 3 Hours) (Exclusion: BIOC 4911 Nucleic Acids) Monday Wednesday and Friday 9:30 to 10:20AM Barclay 217.
In this laboratory course we will explore the essential molecular biology techniques: precise pipetting; PCR primer design; isolation of DNA, RNA and protein from tissue; PCR amplification; DNA separation by agarose gel electrophoresis; gene editing; transcriptional analysis by RT-RT-Q-PCR and quantitative immunoblotting.
This course introduces current topics and advances in Biochemistry and engages students in the scope and activities of the discipline. It examines the central role of water in biological systems, leading to an introduction of acid-base equilibria, the properties of biological membranes, and the bioenergetics of solutes moving across membranes. It introduces the principles of carbon bonding and electronegativity, leading to coverage of the bioorganic functional groups, whose characteristic properties and reactions combine to create the highly complex biological macromolecule classes of carbohydrates, proteins,nucleic acids, and lipids. (Format: Lecture 3 Hours, Tutorial 1.5 Hours) (Distribution: Natural Science-b) Tuesday and Thursday 8:30 to 9:50AM Crabtree M14.